INTRAVITREAL AAV-DELIVERY OF GENETICALLY ENCODED SENSORS ENABLING SIMULTANEOUS TWO-PHOTON IMAGING AND ELECTROPHYSIOLOGY OF OPTIC NERVE AXONS

Intravitreal AAV-Delivery of Genetically Encoded Sensors Enabling Simultaneous Two-Photon Imaging and Electrophysiology of Optic Nerve Axons

Myelination of axons by oligodendrocytes is a key feature of the remarkably fast operating CNS.Oligodendrocytes not only tune axonal conduction speed but are also suggested to maintain long-term axonal integrity by providing metabolic support to the axons they ensheath.However, how myelinating oligodendrocytes impact axonal energy homeostasis remai

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Ca2+ mobilization-dependent reduction of the endoplasmic reticulum lumen is due to influx of cytosolic glutathione

Abstract Background The lumen of the endoplasmic reticulum (ER) acts as a cellular Ca2+ store and a site for Accessories oxidative protein folding, which is controlled by the reduced glutathione (GSH) and glutathione-disulfide (GSSG) redox pair.Although depletion of luminal Ca2+ from the ER provokes a rapid and reversible shift towards a more reduc

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